RESEARCH & FACULTY
CARDIOVASCULAR & PULMONARY BIOLOGY
The cardiovascular system includes the heart and all blood vessels delivering oxygen to tissues and the transporting metabolic waste products to be cleared from the body. The pulmonary system includes the trachea (windpipe), the lungs, the muscles and bones of the rib cage, and the diaphragm. It transports oxygen to the blood and extracts carbon dioxide, along with directly interacting with external pollutants, bacteria, and viruses. Faculty study the molecular features that lead to diseased tissue and aim to leverage this information to design novel treatments and therapeutic strategies.
Mary Weiser-Evans PhD
Professor;
Director, Integrated Physiology Program
Completed Upstander/Bystander Training; Completed Unconscious Bias Workshop; Completed Resecting Others in the Workplace Workshop; Completed CIMER Facilitator Training
Our laboratory focuses on vascular biology, with particular emphasis on smooth muscle cell (SMC) signaling and understanding the regulation of SMC phenotypic modulation in disease.
Phone:3037244846
Carmen Sucharov PhD
Professor
Our main goal is to identify potential new therapeutic agents for the treatment of heart failure.
Phone:3037245409
Catherine Proenza PhD
Professor
One major focus of the lab is to understand the molecular basis for pacemaker activity within individual sinoatrial node myocytes (SAMs). To this end, we use patch clamp electrophysiology to record spontaneous action potentials and membrane currents from isolated SAMs from mice. We also use advanced patch clamp techniques like AP clamp and dynamic clamp to isolate and manipulate individual currents in SAMs.
Phone:3037242522
Irina Petrache MD
Professor
Research interests include: Alpha 1 antitrypsin biology; Chronic Obstructive Pulmonary Disease (COPD); Lung Cell Biology; Lung Inflammation; Lung Injury and Repair; Pulmonary Vascular Disease; Regenerative Medicine; Sphingolipid signaling and metabolomics; and Vascular Biology.
Timothy McKinsey PhD
Professor
Epigenetic regulation of heart failure; signaling and transcriptional mechanisms of muscle disease.
Phone:3037245476
Tim Lahm MD
Professor
Dr. Lahm is a physician scientist in the Division of Pulmonary, Critical Care and Sleep Medicine with a focus on the study of sexual dimorphisms in lung vascular remodeling and right ventricular (RV) adaptation in pulmonary hypertension (PH).
Email:tim.lahm@cuanschutz.edu
Fabrice Dabertrand PhD
Associate Professor
Completed Upstander/Bystander Training; Completed Implicit Bias Training; Completed Mentor Training Course
The control of cerebral blood flow by ion channels and calcium signaling in the pericytes, endothelial cells, and smooth muscle cells that constitute the parenchymal microcirculation, and use this information to combat brain diseases with a vascular component.
Phone:3037243792
Edward Lau PhD
Assistant Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
Our lab has a broad range of research interests, encompassing several areas of biochemistry and cell biology:
(1) Protein turnover: development and application of stable isotope labeling mass spectrometry methods to measure protein half-life.
(2) Spatial proteomics: subcellular distributions of proteins, interaction between spatial and temporal protein dynamics.
(3) Cellular physiology: cellular crosstalk by secretome proteins, signatures of cellular senescence, cardiotoxicity and proteostatic disruptions in induced pluripotent stem cell models.
(4) Bioinformatics: correlation and discrepancies of transcript and protein levels, protein prediction with machine learning.
John Bankston PhD
(He/Him/His)
Associate Professor
Completed Mentor Training Course
We are interested in the molecular mechanisms of cellular excitability in the heart and brain. Our focus is on two different families of ion channels, the acid-sensing ion channels (ASICs) and hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels. We study the structural and physiological mechanisms of channel function for each class of channel including how these channels are regulated by other proteins as well as the lipid membrane. To do this we use a combination of patch clamp, FRET, single-molecule fluorescence, and biochemistry.
STRUCTURAL BIOLOGY
Many of the faculty utilize multi-omics data and molecular structure to define how and where pharmacological processes occur. Knowledge of the omics profiles from an individual allows us to define the target of pharmacologically important molecules. Defining the molecular structure of the target protein allows pharmacological mechanisms of molecules to be defined. The centers and facilities that aid in this research include the Genomics Shared Resource, Mass Spectrometry Center, Nuclear Magnetic Resonance Center, Electron Microscopy Facility, and the X-ray Crystallography Center.
Ulli Bayer PhD
Professor
Completed Mentor Training Course
Our field is molecular and cellular neuroscience. Specifically, we are interested in the molecular and cellular mechanisms underlying learning, memory and cognition. We also want to know how these mechanisms go wrong in disease, and how this could be repaired by new therapeutic strategies.
Phone:3037243610
Edward Lau PhD
Assistant Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
Our lab has a broad range of research interests, encompassing several areas of biochemistry and cell biology:
(1) Protein turnover: development and application of stable isotope labeling mass spectrometry methods to measure protein half-life.
(2) Spatial proteomics: subcellular distributions of proteins, interaction between spatial and temporal protein dynamics.
(3) Cellular physiology: cellular crosstalk by secretome proteins, signatures of cellular senescence, cardiotoxicity and proteostatic disruptions in induced pluripotent stem cell models.
(4) Bioinformatics: correlation and discrepancies of transcript and protein levels, protein prediction with machine learning.
Tatiana Kutateladze PhD
Professor
My laboratory investigates molecular mechanisms of epigenetic regulation and the role of chromatin modifications in human diseases. We use high field NMR spectroscopy and X-ray crystallography to obtain atomic-resolution structures of chromatin-binding proteins and complexes involved in transcription and DNA damage repair.
Phone:3037243593
Joshua Black PhD
Assistant Professor
Completed Mentor Training Course; Completed Implicit Bias Training
My lab studies how cells use epigenetics to control gene amplifications. We have identified epigenetic pathways that cells use to create transient increases in gene copy number. These copy number changes play roles in tumor development, progression and drug resistance. By understanding the fundamental mechanisms that govern copy number control we hope to allow better cancer therapies.
M. Cecilia Caino PhD
(she/her/hers)
Assistant Professor
Facilitated and Completed Mentor Training Course; Completed Upstander/Bystander Training, Completed Equity Certificate,
Our group aims to understand how mitochondria reprogramming in tumors impact cellular behaviors that drive progressive and lethal cancer. We use a broad repertoire of biochemistry, cell biology, live cell imaging and animal models to study the impact of mitochondria shape, number and subcellular distribution in metastatic dissemination.
Benjamin Bitler PhD
Associate Professor
Completed Upstander/Bystander Training
Dr. Bitler is committed to the fight against cancer through his work to elucidate the impact of cancer-related signaling and epigenetic regulation.
Phone:3037240574
SIGNAL TRANSDUCTION
How the activities of different cell types are harmonized to provide integrated responses in an organism is the key feature that allows multi-celled organisms to flourish. This coordination is achieved by the activities of an array of neurotransmitters, hormones, and growth factors, which operate on timescales of milliseconds to days. The study of these processes is known as signal transduction, or cellular signaling, one of the key areas of biomedical research that tells us about normal functions and therapeutic opportunities. The majority of faculty study cellular signaling at some level, including ion channels, signal transduction pathways, second messengers, growth factor-signaling, and the cell cycle.
John Janetzko PhD
(He/Him/His)
Assistant Professor
We study the molecular mechanisms that underpin G protein-coupled receptor (GPCR) signaling in health and disease. Using chemical and structural/biophysical approaches, including single-molecule fluorescence, mass spectrometry and cryo-electron microscopy, we aim to understanding signal transduction at the molecular level. Our work aims to connect fundamental questions in signal transduction with novel approaches to target aberrant GPCR signaling in disease.
David DiGregorio PhD
Professor and Chair
The DiGregorio laboratory studies the role of synaptic and neuronal mechanisms influencing how the brain represents time for executing precise behaviors. Projects in the lab span multiple scales (from molecules to circuits to behavior) but also across multiple disciplines (cellular and molecular neurobiology to theoretical neuroscience).
Jordan Jacobelli PhD
(He/Him/His)
Associate Professor
Completed Upstander/Bystander Training; Completed Implicit Bias Training
Research in the Jacobelli lab focuses on determining how actin network remodeling regulates lymphocyte migration, activation, and effector functions in response to chemotactic, adhesive, and antigenic stimuli. We focus on how cytoskeletal effector molecules, such as Ena/Vasp and Formin proteins, generate the mechanical forces and shape changes required for lymphocyte migration and cell-cell interactions during homeostasis and disease. An additional focus of Dr. Jacobelli’s research program is to identify novel therapeutically relevant targets to treat diseases in which leukocyte migration and trafficking play a critical role, such as autoimmunity and cancer. Our goals are to develop approaches to inhibit self-reactive lymphocyte infiltration into autoimmune disease sites or to enhance lymphocyte migration and efficacy against tumors. To address these questions the Jacobelli lab uses a combination of in vitro reductionist approaches, including high-resolution spatio-temporal imaging of molecular dynamics, and cutting-edge in vivo 2-photon microscopy to characterize immune cell behavior within physiological environments.
Mary Weiser-Evans PhD
Professor;
Director, Integrated Physiology Program
Completed Upstander/Bystander Training; Completed Unconscious Bias Workshop; Completed Resecting Others in the Workplace Workshop; Completed CIMER Facilitator Training
Our laboratory focuses on vascular biology, with particular emphasis on smooth muscle cell (SMC) signaling and understanding the regulation of SMC phenotypic modulation in disease.
Phone:3037244846
Slobodan Todorovic MD, PhD
Professor
Completed DEI Training Course
The role of T-type (low-voltage-activated, LVA) calcium channels in the molecular mechanisms of anesthesia and analgesia.
Katharine Smith PhD
Associate Professor
Completed Upstander/Bystander Training
Research in our lab is focused on understanding how the excitability of neurons is regulated by excitatory and inhibitory synaptic plasticity. Many neuropsychiatric diseases and brain pathologies exhibit alterations in neuronal excitability in key brain regions associated with learning and memory. Our goal is to understand the molecular mechanisms of how excitatory and inhibitory synapses function together to maintain appropriate excitability of the neuron, and how this is disrupted in diseases such as autism and schizophrenia. To reach this goal we image both excitatory and inhibitory synapses using cutting-edge microscopy, including super-resolution imaging, supported by electrophysiology and biochemical analysis.
Nidia Quillinan PhD
Associate Professor
The Quillinan laboratory studies excitability and plasticity changes in the brain following cerebral ischemia. We are particularly interested in cerebellar networks that are affected by stroke and cardiac arrest. We also investigate the role of sex hormones and their receptors in acute neuronal injury and longterm hippocampal function.
Catherine Proenza PhD
Professor
One major focus of the lab is to understand the molecular basis for pacemaker activity within individual sinoatrial node myocytes (SAMs). To this end, we use patch clamp electrophysiology to record spontaneous action potentials and membrane currents from isolated SAMs from mice. We also use advanced patch clamp techniques like AP clamp and dynamic clamp to isolate and manipulate individual currents in SAMs.
Phone:3037242522
Won Chan Oh PhD
Assistant Professor
Completed Upstander/Bystander Training
We use advanced optical imaging techniques to examine the spatiotemporal mechanisms that govern activity-dependent excitatory and inhibitory synaptic and circuit plasticity in the developing cortex.
Timothy McKinsey PhD
Professor
Epigenetic regulation of heart failure; signaling and transcriptional mechanisms of muscle disease.
Phone:3037245476
Tim Lahm MD
Professor
Dr. Lahm is a physician scientist in the Division of Pulmonary, Critical Care and Sleep Medicine with a focus on the study of sexual dimorphisms in lung vascular remodeling and right ventricular (RV) adaptation in pulmonary hypertension (PH).
Email:tim.lahm@cuanschutz.edu
Matthew Kennedy PhD
Professor
Completed Mentor Training Course; Completed Implicit Bias Training
We study how synapses in the central nervous system are modified by experience, with the ultimate goal of understanding how these mechanisms contribute to normal cognitive function and how they break down in various brain diseases and disorders.
Christopher Ford PhD
Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
Our lab examines how neuromodulators are encoded in the mesolimbic and nigrostriatal systems and how circuit dysfunctions in these areas contribute to neurological and psychiatric disorders.
Phone:3037243463
Mark Dell'Acqua PhD
Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training; Completed DEI Training
My laboratory’s specific research in the area of neuropharmacology focuses on understanding how cAMP and calcium second messenger signaling pathways are organized at the postsynaptic specializations of excitatory neuronal synapses.
Fabrice Dabertrand PhD
Associate Professor
Completed Upstander/Bystander Training; Completed Implicit Bias Training; Completed Mentor Training Course
The control of cerebral blood flow by ion channels and calcium signaling in the pericytes, endothelial cells, and smooth muscle cells that constitute the parenchymal microcirculation, and use this information to combat brain diseases with a vascular component.
Phone:3037243792
Ulli Bayer PhD
Professor
Completed Mentor Training Course
Our field is molecular and cellular neuroscience. Specifically, we are interested in the molecular and cellular mechanisms underlying learning, memory and cognition. We also want to know how these mechanisms go wrong in disease, and how this could be repaired by new therapeutic strategies.
Phone:3037243610
Jason Aoto PhD
Associate Professor;
Director, Pharmacology Program
Completed Mentor Training Course
We employ cutting-edge approaches including mouse genetics, optogenetics, viral circuit tracing, ex vivo slice electrophysiology, CRISPR/cas9 genome editing, single-cell RNA-sequencing and super-resolution microscopy to investigate how disease-relevant synaptic molecules are utilized in a cell-type- and synapse-specific manner in neural circuits implicated in neuropsychiatric disorders and addiction.
John Bankston PhD
(He/Him/His)
Associate Professor
Completed Mentor Training Course
We are interested in the molecular mechanisms of cellular excitability in the heart and brain. Our focus is on two different families of ion channels, the acid-sensing ion channels (ASICs) and hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels. We study the structural and physiological mechanisms of channel function for each class of channel including how these channels are regulated by other proteins as well as the lipid membrane. To do this we use a combination of patch clamp, FRET, single-molecule fluorescence, and biochemistry.
Chandra Tucker PhD
Professor
Completed Mentor Training Course
Research in the Tucker Lab focuses on developing new tools to sense and manipulate the intracellular environment, and using these tools to understand dynamic cellular processes. A major focus is in developing ways that we can inducibly regulate and control fundamental molecular events such as protein trafficking, proteolysis, gene expression, and intracellular signaling using inducers such as light (optogenetic tools) or chemicals.
Phone:3037246337
Lori Sussel PhD
Professor;
Director of Research, Barbara Davis Center for Diabetes
Completed Mentor Training Course
We are interested in the molecular mechanisms regulating pancreatic islet function in normal and disease conditions. In particular, we study the transcriptional programs, long non-coding RNAs, and RNA processing events that regulate pancreatic identity and function and how disruption of these programs leads to islet dysfunction and diabetes.
Phone:3037249119
CANCER BIOLOGY
Our faculty are developing a detailed understanding of the underlying
molecular mechanisms that drive cancer cell behavior and then applying this
understanding to develop better, more tailored treatments for cancer. Faculty
are also members of the University of Colorado Cancer Center to translate
findings into the clinic. Specific areas of cancer biology research include: cancer drug resistance, metastasis, and tumor cell growth and death. We leverage cutting-edge technologies, in single cell multi-omic approaches, multispectral imaging, cell biology, structural biology, biochemistry, genetics, and systems biology.
Joe Nassour PhD
Assistant Professor
My lab is interested in studying the molecular connections between aging and cancer. The focus is on understanding how the shortening of telomeres during cellular aging triggers autophagy and innate immune signaling pathways to suppress the early stages of tumor development. Our overarching goal is to deepen our understanding of cancer biology and develop innovative strategies to combat this disease.
Jordan Jacobelli PhD
(He/Him/His)
Associate Professor
Completed Upstander/Bystander Training; Completed Implicit Bias Training
Research in the Jacobelli lab focuses on determining how actin network remodeling regulates lymphocyte migration, activation, and effector functions in response to chemotactic, adhesive, and antigenic stimuli. We focus on how cytoskeletal effector molecules, such as Ena/Vasp and Formin proteins, generate the mechanical forces and shape changes required for lymphocyte migration and cell-cell interactions during homeostasis and disease. An additional focus of Dr. Jacobelli’s research program is to identify novel therapeutically relevant targets to treat diseases in which leukocyte migration and trafficking play a critical role, such as autoimmunity and cancer. Our goals are to develop approaches to inhibit self-reactive lymphocyte infiltration into autoimmune disease sites or to enhance lymphocyte migration and efficacy against tumors. To address these questions the Jacobelli lab uses a combination of in vitro reductionist approaches, including high-resolution spatio-temporal imaging of molecular dynamics, and cutting-edge in vivo 2-photon microscopy to characterize immune cell behavior within physiological environments.
Michael Verneris MD
Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
My research studies are aimed at developing cellular therapy to reduce leukemia recurrence by enhancing immune recovery and by more effectively treating sites of leukemia (with a newly developed method of bone marrow irradiation).
Raul Torres PhD
Professor
We have a long-standing interest in investigating the mechanisms by which B lymphocytes develop and subsequently mount antibody responses to foreign antigens and pathogens. In the recent past we have particularly focused on understanding how the distinct B cell populations that exist in humans and mice act in concert to provide humoral immunity. To address these issues, we rely on molecular, genetic and biochemical in vitro and in vivo approaches that often rely on genetically-engineered mouse models. More recent work in our lab has revealed that a bioactive lipid, lysophosphatidic acid (LPA), is able to suppress signaling by both B and T lymphocyte antigen receptors and specifically upon engagement with the LPAR5 receptor.
Phone:3037248669
Tatiana Kutateladze PhD
Professor
My laboratory investigates molecular mechanisms of epigenetic regulation and the role of chromatin modifications in human diseases. We use high field NMR spectroscopy and X-ray crystallography to obtain atomic-resolution structures of chromatin-binding proteins and complexes involved in transcription and DNA damage repair.
Phone:3037243593
Joshua Black PhD
Assistant Professor
Completed Mentor Training Course; Completed Implicit Bias Training
My lab studies how cells use epigenetics to control gene amplifications. We have identified epigenetic pathways that cells use to create transient increases in gene copy number. These copy number changes play roles in tumor development, progression and drug resistance. By understanding the fundamental mechanisms that govern copy number control we hope to allow better cancer therapies.
Craig Jordan PhD
(he/him/his)
Professor
Completed Mentor Training Course
Dr. Jordan serves as the Chief of the Hematology Division and directs a research program focused on the development of novel therapies for the treatment of leukemia.
Phone:3037248165
Heide Ford PhD
(she/her/hers)
Professor
Completed Mentor Training Course
Our laboratory focuses on a specific family of homeoproteins, the Six family, and their transcriptional cofactors, Eya and Dach. The Six1 homeobox gene is overexpressed in 50% of primary breast cancers and 90% of metastatic lesions, and its overexpression.
Phone:3037243509
Joaquin Espinosa PhD
Professor
Our main research goal is to understand how gene networks control cell behavior in homeostasis and human disease. Our two main focus areas are cancer biology and Down syndrome.
Phone:3037247389
Patricia Ernst PhD
(she/her/hers)
Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
Our group focuses on epigenetic mechanisms regulating normal hematopoiesis and leukemia focusing on MLL-family histone methyltransferases.
Phone:3037248804
James Costello PhD
(he/him/his)
Associate Professor;
Director, Pharmacology Program
Completed Upstander/Bystander Training, Completed Mentor Training Course
Within the broad scope of systems biology, my lab focuses on 3 research areas: 1) Network inference for identifying drug targets, 2) Predicting drug sensitivity from -omics datasets, and 3) Modeling temporal effects of drug combinations.
Phone:3037248619
M. Cecilia Caino PhD
(she/her/hers)
Assistant Professor
Facilitated and Completed Mentor Training Course; Completed Upstander/Bystander Training, Completed Equity Certificate,
Our group aims to understand how mitochondria reprogramming in tumors impact cellular behaviors that drive progressive and lethal cancer. We use a broad repertoire of biochemistry, cell biology, live cell imaging and animal models to study the impact of mitochondria shape, number and subcellular distribution in metastatic dissemination.
Benjamin Bitler PhD
Associate Professor
Completed Upstander/Bystander Training
Dr. Bitler is committed to the fight against cancer through his work to elucidate the impact of cancer-related signaling and epigenetic regulation.
Phone:3037240574
Rebecca Schweppe PhD
(she/her/hers)
Professor and Director, Cancer Biology Program
Completed Mentor Training Course
The focus of my lab is to identify novel molecular targets relevant to papillary and anaplastic thyroid cancer (PTC and ATC) with the ultimate goal of advancing these studies to clinical trials for thyroid cancer patients who do not respond to standard treatment. Trainings Completed: Certificate in Multicultural Mentoring, Implicit Bias Training, Bystander/Upstander Training, Active Listening Training to Support Student Mental Health
Phone:3037243179
Matthew Sikora PhD
(he/him/his)
Associate Professor
Completed Mentor Training Course
The overall goal of the Sikora Laboratory is to understand mechanisms of response and resistance to steroid hormones and anti-estrogen therapies in breast cancer, with a special emphasis on invasive lobular carcinoma of the breast.
Phone:3037244301
COMPUTATIONAL BIOLOGY & PERSONALIZED MEDICINE
Faculty utilize the human genome, transcriptome, proteome, metabolome, and molecular structure to define how and where pharmacological processes occur. Studying biological systems is complex and drawing statistical inferences from large compendium data of genetic factors requires novel computational methodology and compute infrastructure. Faculty are designing the methods to translate these large datasets into knowledge.
Specific areas of computational biology and personalized medicine include systems pharmacology, development of network inference methods, prediction of novel gene function, genome and transcriptome-wide association studies, machine learning and artificial intelligence, and structure modeling. Faculty also have a strong interest in the ethical concerns raised with applying artificial intelligence models and the collection of large training and testing datasets.
Laura Saba PhD
Associate Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
We utilize and develop systems genetics tools to explore biological mechanisms responsible for disease.
Phone:3037249697
Arjun Krishnan PhD
Associate Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
Our group develops machine learning (ML)- and AI-based methods and tools that take advantage of diverse and massive public data collections to gain nuanced insights into the genetic, molecular, and cellular basis of complex diseases. The data collections we work with include genotype-phenotype associations, bulk and single-cell omics profiles, genome-scale molecular networks, unstructured text corpora, and ontologies/knowledgebases. Our methods and tools enable biomedical researchers to reuse these public data effectively, seamlessly, and at scale to generate novel data-driven hypotheses about a variety of biomedical contexts. We are also passionate about rapid and open science, well-rounded professional training, and creating diverse and inclusive learning environments.
Casey Greene PhD
Professor
Completed Upstander/Bystander Training; Completed Maximizing Mentoring
The Greene lab focuses on performing open, reproducible, and inclusive research on topics at the intersection of machine learning, public data, and the transcriptome.
Phone:3037240318
Edward Lau PhD
Assistant Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
Our lab has a broad range of research interests, encompassing several areas of biochemistry and cell biology:
(1) Protein turnover: development and application of stable isotope labeling mass spectrometry methods to measure protein half-life.
(2) Spatial proteomics: subcellular distributions of proteins, interaction between spatial and temporal protein dynamics.
(3) Cellular physiology: cellular crosstalk by secretome proteins, signatures of cellular senescence, cardiotoxicity and proteostatic disruptions in induced pluripotent stem cell models.
(4) Bioinformatics: correlation and discrepancies of transcript and protein levels, protein prediction with machine learning.
Gregory Way PhD
Assistant Professor
Completed Upstander/Bystander Training; Completed Mentor Training Course
The mission of our lab is to reduce human suffering by integrating biomedical data science and software engineering into drug discovery by developing new computational methods, innovative approaches, assays, and software for analyzing high-dimensional genomic, molecular, and microscopy data with a focus on pediatric diseases, including pediatric cancer and Neurofibromatosis Type 1 (NF1).
James Costello PhD
(he/him/his)
Associate Professor;
Director, Pharmacology Program
Completed Upstander/Bystander Training, Completed Mentor Training Course
Within the broad scope of systems biology, my lab focuses on 3 research areas: 1) Network inference for identifying drug targets, 2) Predicting drug sensitivity from -omics datasets, and 3) Modeling temporal effects of drug combinations.
Phone:3037248619
NEUROPHARMACOLOGY
Faculty working in the area of neuroscience and neuropharmacology focus their research on characterizing the cellular and molecular mechanisms that underlie neuronal function and behavior. Because neuroscience/neuropharmacology is an increasingly integrative discipline, we incorporate cutting-edge multidisciplinary approaches including animal behavior, advanced microscopy, in vivo measurements of neural activity, electrophysiology, optogenetics and molecular and cell biology. One of the strengths of our faculty lies in the fact that they have experience in a number of different scientific disciplines.
Specific areas of neuropharmacology research at CU Anschutz include the study of molecular memory and synaptic plasticity, neurodegenerative diseases and molecular mechanisms that control synaptic transmission and neuromodulation. In addition, the pharmacology faculty has a particularly strong interest in the neuropharmacology of psychedelics and drugs of abuse.
John Janetzko PhD
(He/Him/His)
Assistant Professor
We study the molecular mechanisms that underpin G protein-coupled receptor (GPCR) signaling in health and disease. Using chemical and structural/biophysical approaches, including single-molecule fluorescence, mass spectrometry and cryo-electron microscopy, we aim to understanding signal transduction at the molecular level. Our work aims to connect fundamental questions in signal transduction with novel approaches to target aberrant GPCR signaling in disease.
Justin O'Hare PhD
Assistant Professor
We investigate how a neuron’s dendritic arbor supports the formation of new, experience-dependent receptive fields that serve as building blocks for new memories. Using place fields in mouse hippocampal area CA1 as a model system, we combine molecular and systems neuroscience approaches to understand (1) how dendrites integrate multiple, complementary streams of synaptic input from distinct brain circuits to inform somatic action potential firing and (2) how these dendritic integrative rules are updated during place field formation and behaviorally-manifested learning.
David DiGregorio PhD
Professor and Chair
The DiGregorio laboratory studies the role of synaptic and neuronal mechanisms influencing how the brain represents time for executing precise behaviors. Projects in the lab span multiple scales (from molecules to circuits to behavior) but also across multiple disciplines (cellular and molecular neurobiology to theoretical neuroscience).
Kimberley Bruce PhD
Associate Professor
Completed Upstander/Bystander Training
Many neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease (AD) are more prevalent in women and have a marked impact on physical and mental health. Female sex is a major risk factor for late-onset AD, and females carrying the APOE4 gene are more likely to develop severe AD. Despite these well-known associations, the reason for this increased risk is unclear. Recent work from Dr. Bruce's laboratory has shown that females have enhanced fat and cholesterol metabolism in specialized brain cells, which may be detrimental in the presence of AD risk factors such as APOE4.
Slobodan Todorovic MD, PhD
Professor
Completed DEI Training Course
The role of T-type (low-voltage-activated, LVA) calcium channels in the molecular mechanisms of anesthesia and analgesia.
Katharine Smith PhD
Associate Professor
Completed Upstander/Bystander Training
Research in our lab is focused on understanding how the excitability of neurons is regulated by excitatory and inhibitory synaptic plasticity. Many neuropsychiatric diseases and brain pathologies exhibit alterations in neuronal excitability in key brain regions associated with learning and memory. Our goal is to understand the molecular mechanisms of how excitatory and inhibitory synapses function together to maintain appropriate excitability of the neuron, and how this is disrupted in diseases such as autism and schizophrenia. To reach this goal we image both excitatory and inhibitory synapses using cutting-edge microscopy, including super-resolution imaging, supported by electrophysiology and biochemical analysis.
Nidia Quillinan PhD
Associate Professor
The Quillinan laboratory studies excitability and plasticity changes in the brain following cerebral ischemia. We are particularly interested in cerebellar networks that are affected by stroke and cardiac arrest. We also investigate the role of sex hormones and their receptors in acute neuronal injury and longterm hippocampal function.
Won Chan Oh PhD
Assistant Professor
Completed Upstander/Bystander Training
We use advanced optical imaging techniques to examine the spatiotemporal mechanisms that govern activity-dependent excitatory and inhibitory synaptic and circuit plasticity in the developing cortex.
Matthew Kennedy PhD
Professor
Completed Mentor Training Course; Completed Implicit Bias Training
We study how synapses in the central nervous system are modified by experience, with the ultimate goal of understanding how these mechanisms contribute to normal cognitive function and how they break down in various brain diseases and disorders.
Christopher Ford PhD
Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training
Our lab examines how neuromodulators are encoded in the mesolimbic and nigrostriatal systems and how circuit dysfunctions in these areas contribute to neurological and psychiatric disorders.
Phone:3037243463
Robert Dietz MD, PhD
Assistant Professor
Completed Upstander/Bystander Training
Strategies for restoration of synaptic plasticity following cerebral ischemia.
Mark Dell'Acqua PhD
Professor
Completed Mentor Training Course; Completed Upstander/Bystander Training; Completed DEI Training
My laboratory’s specific research in the area of neuropharmacology focuses on understanding how cAMP and calcium second messenger signaling pathways are organized at the postsynaptic specializations of excitatory neuronal synapses.
Fabrice Dabertrand PhD
Associate Professor
Completed Upstander/Bystander Training; Completed Implicit Bias Training; Completed Mentor Training Course
The control of cerebral blood flow by ion channels and calcium signaling in the pericytes, endothelial cells, and smooth muscle cells that constitute the parenchymal microcirculation, and use this information to combat brain diseases with a vascular component.
Phone:3037243792
Jason Christie PhD
Professor
The Christie Lab endeavors to understand the neural-circuit-mechanisms that underlie the learning-dependent optimization of behavior. The lab’s approach mainly focuses on the cerebellum, a brain region that guides adaptive updating of simple reflexive movements as well as experience-driven refinement of high-order brain function (e.g., thinking, planning, and decision making).
Timothy Benke MD, PhD
Professor
My laboratory studies the function of synapses, the primary means of communication between neurons in the brain. Discoveries include mechanisms for synaptic changes that are likely associated with learning and memory. Research is directed at discovering how synapses change with development and following seizures. Our results are specifically directed to help prevent and treat the effects of early-life seizures (ELS), which can include autism, learning impairment and epilepsy.
Email:tim.benke@cuanschutz.edu
Ulli Bayer PhD
Professor
Completed Mentor Training Course
Our field is molecular and cellular neuroscience. Specifically, we are interested in the molecular and cellular mechanisms underlying learning, memory and cognition. We also want to know how these mechanisms go wrong in disease, and how this could be repaired by new therapeutic strategies.
Phone:3037243610
Jason Aoto PhD
Associate Professor;
Director, Pharmacology Program
Completed Mentor Training Course
We employ cutting-edge approaches including mouse genetics, optogenetics, viral circuit tracing, ex vivo slice electrophysiology, CRISPR/cas9 genome editing, single-cell RNA-sequencing and super-resolution microscopy to investigate how disease-relevant synaptic molecules are utilized in a cell-type- and synapse-specific manner in neural circuits implicated in neuropsychiatric disorders and addiction.
John Bankston PhD
(He/Him/His)
Associate Professor
Completed Mentor Training Course
We are interested in the molecular mechanisms of cellular excitability in the heart and brain. Our focus is on two different families of ion channels, the acid-sensing ion channels (ASICs) and hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels. We study the structural and physiological mechanisms of channel function for each class of channel including how these channels are regulated by other proteins as well as the lipid membrane. To do this we use a combination of patch clamp, FRET, single-molecule fluorescence, and biochemistry.
Emily Bates PhD
(She/Her/Hers)
Associate Professor
Completed Mentor Training Course
We study how ion channel activity (bioelectricity) contributes to morphological development in multiple tissues (craniofacial structures, fly wings, brain, pancreas, and bone).
Phone:3037248303
PHARMACOLOGY AFFILIATE FACULTY
PharMM affiliated faculty are not available to serve as primary PhD mentors, but are available to serve on mentoring teams and student committees.
Mair Churchill PhD
Professor
Research Focus:
Accepting Students
Chromosome Biology
Gene Regulation
Genomics Bioinformatics
Macromolecular Structure
Microbiology Virology
Structural Biology
My lab is interested in understanding the molecular basis of essential processes that regulate gene expression. We use biophysical, biochemical methods, and structural methods, including X-ray crystallography. Our insights into these fundamental mechanisms will contribute to a better understanding and ability to regulate gene expression processes involved in human diseases and will assist in drug development efforts.
Our studies focus on the following questions: (1) How is chromatin structure modulated for DNA-dependent processes? and (2) How do transcription factors and pioneering factors activate gene expression?
Scott Cramer PhD
Professor
Research Focus:
Accepting Students
Cancer Biology
Genomics Bioinformatics
Prostate Cancer Tumor Suppressors, Stem Cells, Tumor Initiating cells, Signal Transduction, Receptor Signaling.
Charles Edelstein MD, PhD
Professor
Research Focus:
Accepting Students
Signal Transduction
Caspases and apoptosis in Polycystic kidney Disease (PKD).
Elan Eisenmesser PhD
Associate Professor
Research Focus:
Accepting Students
Cancer Biology
Signal Transduction
The Eisenmesser lab takes a unique approach to understand protein function, and particularly enzyme function, by utilizing molecular engineering methods to control both structural interactions and the underlying movements that underlie their conformational changes. The ultimate goal of the Eisenmesser lab is to fully characterize molecular interactions at both atomic resolution and biological levels with a particular emphasis on medically relevant systems that may be exploited to either block or promote events underlying disease progression.
David Jones PhD
Associate Professor
Research Focus:
Accepting Students
Structural Biology
Research in my lab uses NMR spectroscopy, X-ray crystallography, molecular biology and biophysical approaches to answer the fundamental questions of how mediators of signal transduction interact with proteins of neuronal signaling pathways.
J. David Port PhD
Professor
Research Focus:
Cardiovascular & Pulmonary Biology
Genomics Bioinformatics
Signal Transduction
G-protein linked receptors and their regulation; regulation of mRNA stability.