Investigations suggest that, in some fields, at least one-quarter of clinical trials might be problematic or even entirely made up, warn some researchers. They urge stronger scrutiny. Lisa Bero, PhD and colleagues acknowledge trustworthiness checks are sometimes unfair to the authors of randomized controlled trials, and exactly what should be checked to classify untrustworthy research, is still up for debate.  Bero and a team of research-integrity experts have developed a set of red flags that might serve as the basis for creating a widely agreed method of assessment.  Read article>>